Four direct oral anticoagulants were approved by the FDA in the last few years and are all now indicated for the treatment of DVT and PE. These include:
Direct thrombin inhibitor:
-Dabigatran (Pradaxa)
Factor Xa inhibitors:
-Rivaroxaban (Xarelto) -Apixaban (Eliquis) -Edoxaban (Savaysa) These medications are given orally at fixed doses and do not require coagulation monitoring or titration. Compared to warfarin (which needs close INR following and can vary drastically
